Accumulation of p53 protein in astrocytomas: Immunohistochemical study using D07 MAb

Abstract

Accumulation of p53 protein was examined in tissue sections of 40 astrocytomas and compared with the histological grade of tumor, age and sex of the patients. Immunohistochemical staining with monoclonal antibody (D07) was positive in 15.4% of grade II and 45% of grade III-IV astrocytoma cases; whereas none of the pilocytic astrocytomas (grade I) were positive for p53. Immunoreactivity showed a strong correlation with tumor grade. There was no significant difference between age and sex of p53 positive and negative cases. [Turk J Cancer 1995;25(4):149-54]