Pleomorphic lobular carcinoma of the breast: Brief communication

Abstract

Some invasive lobular carcinomas of the breast have cells that are more pleomorphic. A 70 years old woman with left breast and axillary mass was operated. The tumor composed of very large cells with eosinophilic cytoplasm and pleomorphic nuclei. Some cells contained intracytoplasmic lumina and Periodic acid-Schiff positive globules. Since pleomorphic lobular carcinoma (PLC) is reported as a very aggressive tumor and the grading of lobular carcinoma is difficult, recognition of the pleomorphic subtype is useful in identifying a lethal variant.

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