The value of real-time myocardial contrast echocardiography for detecting coronary microcirculation function in coronary artery disease patients

Özet

Objective: The aim of this study was to evaluate the value of real-time myocardial contrast echocardiography (RT-MCE) for detecting coronarymicrocirculation (CM) function in coronary artery disease (CAD) patients.Methods: Sixty-five consecutive patients were divided into CAD (n=52) and no-CAD (n=13) groups using coronary angiography (CAG). All patientsunderwent RT-MCE at rest and CAG within 1 week after RT-MCE. The ventricular segments in CAD patients were divided semi-quantitatively intoischemic and non-ischemic myocardial groups based on RT-MCE images. Myocardial blood volume (A), myocardial blood flow velocity (β), andmean myocardial blood flow (Aβ) were obtained. The Gensini scores were calculated for CAD patients. The receiver operating characteristic(ROC) curve areas of A, β, and Aβ were calculated to assess CM function in CAD patients.Results: A total of 798 and 204 segments were investigated in the CAD and non-CAD groups, respectively. In CAD patients, 332 ischemic and466 non-ischemic segments were identified. The values of A, β, and Aβ were significantly different among non-CAD, CAD, ischemic, and nonischemicgroups. ROC curve areas of A, β, and Aβ were 0.85, 0.79, and 0.83, respectively, and significant differences were observed in thesevalues among three Gensini score groups of the CAD patients.Conclusion: Varying degrees of CM function deterioration was observed in CAD patients both in ischemic and non-ischemic areas, with thedeterioration being more sever in the former.