Increased microvolt T-wave alternans in children and adolescents with Eisenmenger syndrome

Özet

Objective: To determine the values of microvolt T-wave alternans (MTWA) in children and adolescents with Eisenmenger syndrome (ES) andcontrols.Methods: Thirteen were included in the study. After analyzing the 24-h ECG recordings, MTWA was considered using three leads (V5, V1, andaVF). Right heart catheterization and 6-minute walk test (6-MWD) were applied to the patients and pro-brain natriuretic peptide levels were assessed;echocardiographic parameters were obtained from both the groups and the results were compared.Results: The MTWA value in lead V5 was 81.08±10.73 µV in the patient group (63.50±18.78 µV in the control group), in lead V1 was 75.00±16.86µV (73.94±16.77 µV in the control group), and in lead aVF was 73.77±17.81 µV (72.61±16.21 µV in the control group). Comparison of MTWA valuesbetween patients and controls revealed that only lead V5 values were statistically different in the ES group. The 6-MWD scores significantlycorrelated with lead V5. Right atrial volume and right ventricular fractional area change were significantly correlated with lead V1. The Tei indexwas significantly correlated with lead aVF.Conclusion: The MTWA lead V5 value was significantly higher in children with ES than in controls and was also correlated with decreasedexercise tolerance