Clinical and pathological evaluation of histopathological subtypes in patients with non-Hodgkin's lymphoma

Abstract

Objectives. Non-Hodgkin Lymphomas (NHLs) are tumours of the lymphoid system which originate fromlymph nodes or extranodal lymphatic tissue. Since they represent a heterogeneous group of diseases, it is veryimportant to determine prognostic factors apart from staging and identification of the patients with poorprognosis. The objective of our study is to investigate clinical characteristics, treatments applied, and theiroutcomes, survival rates, and prognostic factors which may be effective on survival. Methods. Clinicalcharacteristics, treatments applied, and their outcomes, survivals, and prognostic factors which may be effectiveon the survival in 230 patients who were diagnosed as NHL, and consulted to our center between the years2002, and 2015 were retrospectively evaluated. Results. Median age of our patients (male, 54.8 %, and female,45.2 %) was 57 years. The most frequently seen histopathological subtype was diffuse large ? cell lymphoma.We have seen that IPI score, ? symptom, levels of LDH, albumin, ?2 microglobulin, and lymphocyte countsare significant prognostic factors. Stomach was the most frequently involved extranodal organ. Advanced stage,higher IPI score, extranodal organ involvement were found to be correlated with shorter survival times.Conclusion. Everyday developments occur in the diagnosis, classification, and treatment of NHL. Therefore,it is important for medical centres to evaluate their treatment outcomes, and prognostic factors affecting theirsurvival rates.