Thiol/disulphide homeostasis in H. pylori infected patients

Özet

Objectives: The aim of the study was to evaluate the oxidative stress level in patients, diagnosed with H. pyloriinfection, using a novel marker (thiol/disulphide homeostasis) and to compare the level in infected individualswith that in healthy volunteers.Methods: A total of 60 patients diagnosed with gastritis, erosive gastritis or ulcer by endoscopy were includedand biopsied. The 30 patients diagnosed with H. pylori and 30 healthy individuals were enrolled. Medicalhistories, physical examination results, body mass index (BMI), hemogram, free triiodothyronine (FT3), freethyroxine (FT4), thyroid stimulating hormone (TSH), urea, creatinin, aspartate aminotransferase (AST), alanineaminotransferase (ALT), albumin, total cholesterol, triglycerides, high density lipoprotein (HDL), low densitylipoprotein) LDL and thiol/disulphide levels obtained in the study groups were compared.Results: There was no significant difference between the total thiol, native thiol, disulphide/native thiol anddissulphide/total thiol ratios of the patient and control group. When the H. pylori patients were stratified byendoscopic evaluation as having mild (superficial gastritis or normal appearance) or severe (ulcer or erosiveareas) symptoms, there were significant differences in disulphide, disulphide/native thiol, disulphide/total thioland native thiol/total thiol levels. We also observed BMI and the total, native thiol levels of H. pylori patientswere inversely related.( r: 0.562, p = 0.001; r: 0.0552, p = 0.002).Conclusions: Thiol/disulphide homeostasis is likely to differ with both duration and severity of H. pyloriinfection. Further investigations are needed to investigate the effect of H. pylori on oxidative stress.