Anticardiolipin antibody levels in ischemic stroke

Abstract

PURPOSE: Many aetiological risk factors have been known to play important roles in the development of ischemic cerebrovascular diseases. Among these risk factors, attention has been focused on high levels of anticardiolipin antibodies(ACA). This study aims to evaluate levels of ACA IgG and IgM in ischemic cerebrovascular diseases. MATERIAL AND METHOD: This study includes 60 patient and a control group of 30. in the study, for each patientbrain imaging study (CT or MRI), echocardiography (TTE or TEE), doppler USG and rutin heamatological examinationswere also performed. Levels of ACA IgG and IgM were studies in the serum samples taken from each patient within the first week. FINDINGS: The patients (n:60) and the control group (n:30) were divided into age groups of under 40,40-60 and over 60. When examined according to age, statisticaly, no significant differences were found. in the patient group average levels of IgG ACA (PLU/ml) were 4.15 for the first group, 4.40 for the second and 3.55 for the third group. Average levels of IgM ACA (PLU/ml) were 4.85, 3.10 and 1.70 respectively. As for the control group average levels ogf IgG ACA were 3.20, 3.10, 4.60 PLU/ml, and average levels of IgM ACA weere 2.60, 4.80,1.50 PLU/ml respectively. CONCLUSION: According to our data, there has been no significant differences statisticaly, in levels of IgG and IgM ACA between the patient and control group (p>0.05), which suggests that these levels do not constitute risk factors in stroke.

Özet

AMAÇ: Iskemik serebrovasküler hastalığın gelişiminde birçok etyolojik faktör rol oynamaktadır. Son zamanlarda bu faktörler arasında antikardiolipin antikor (AÇA) düzeylerinin yüksekliği üzerinde durulmaktadır. Bu çalışmada tıkayıcı tip serebrovasküler hastalıklarda AÇA IgG ve AÇA IgM düzeylerinin değerlendirilmesi amaçlanmıştır. GEREÇ ve YÖNTEM: Çalışmaya 60 hasta ve 30 kişiden oluşan kontrol grubu alınmıştır. Çalışmaya alınan her hastanın bilgisayarlı beyin tomografisi (BBT), bazı olgularda manyetik rezonans görüntüleme (MRG), transtorasik ve gereken olgularda transözef agial ekokardiograf i (TTE /TEE), karotis-vertebral doppler ultrasonograf i ve rutin hematolojik tetkikler yapılmış ve her hastadan ilk bir hafta içinde alman serum örneklerinde IgG ve IgM AÇA düzeyleri çalışılmıştır. BULGULAR: Çalışmaya alınan hastalar (n:60) ve kontrol olguları (n:30) 40 yaş altı, 40 0.05).