Journals / Üroloji Bülteni / 1999 / Cilt: 10 - Sayı: 3
The early effects of diabetes mellitus on cavernosal tissue
- Journal
- Üroloji Bülteni
- Pages
- 137–140
- DOI
- —
Abstract
The Early Effects Of Diabetes Mellitus On Cavernosal Tissue- Objective: To investigate the early effects of diabetes mellitus on cavernosal tissues in rats. Materials and Methods: Diabetes mellitus was induced in 25 adult Sprague-Dawley rats by intraperitoneal injection of 60 mg/kg streptozocin. Fifteen rats were used as controls. After three months, the cavernosal tissues were evaluated by using light microscopy and transmission electron microscopy. Results: Histological examination of penile and cavernosal tissues either with light or transmission electron microscopy revealed similar finding's in both groups. The venous and arterial systems, endothelial cells and cavernosal smooth muscles were entirely normal despite diabetes mellitus. Conclusion: Diabetes mellitus causes erectile dysfunction without inducing any detectable light or transmission electron microscopic effects on penile structures in the early period. Early erectile dysfunction may possibly be related to the quantitative and /or qualitative effects on neurotransmitters.
Özet
Amag: Ratlarda diabetes mellitusun kavernozal doku uzerine erken donemdeki etkilerinin arastinlmasi. Gereg ve Yontem: Yirmi adult Sprague-Dawley rat 60 mg/kg intraperitoneal streptozosin enjeksiyonu ile diyabetik hale getirildi. Onbe§ rat kontrol grubu dlarak birakildi. Uc ayhk izlem sonunda kavernozal doku i§ik ve transmisyon elektron mikroskop (TEM) kullanilarak degerlgndirildi. Bulgular: Penis ve tunika albugineanin i§ik mikroskop ve TEM incelemesinde, diyabetik ve kontrol gr|.bu ratlar arasinda belirgin fark yoktu. Venbz ve arteriyel sistemler, endotelyal hucreler ve kavernozal duz kaslar tamamen normaldi. Sonug: Diabetes mellitus, erken donemde penisin histopatolojik yapisi uzerinde isik ve elektron mikroskobik duzeyde herhangi bir degisiklik yapmadan erektil disfonksiyon olu§turmaktadir. Bunun nedeni norotransmitter duzeyinde ve/veya etkisinde yaptigi degisiklikler olabilir.