The Effects of Propylthiouracil on Small Intestine of Mice: A Light and Electron Microscobical Study

Abstract

In this study, the effect of propylthiouracil on epithelial cells of the small intestine is examined by histological and cytological methods. As a result of histologic analyses an increase in PAS positive reaction was observed in the intestinal epithelium of the experimental group given PTU for 1 month. As a result of cytologic examination, administration of PTU for 1 month to rats induced marked ultrastructural changes in the small intestinal epithelium. As a result, we can conclude that PTU causes significant structural changes and stimulates its synthesis and secretion functions in the small intestinal epithelium