Karabük İlinde Hepatit C Virüsünün Genotip Dağılımı ve Olguların Demografik Özellikleri

Genotype Distribution of Hepatitis C Virus and Demographic Features of The Patients in The Province of Karabük

Abstract

Amaç: Hepatit C virüsü (HCV) infeksiyonu olan olgularda HCV genotip dağılımının belirlenmesi ve hastaların demografik bilgilerin saptanması amaçlanmıştır. Gereç ve Yöntemler: Hastanemiz mikrobiyoloji laboratuvarında Ocak 2016-Aralık 2019 tarihleri arasında HCV genotiplendirmesi yapılan erişkin hastalar çalışmaya dahil edilmiştir. Olguların yaş ve cinsiyeti geriye dönük olarak hastane kayıtlarından incelenmiştir. Bulgular: Çalışmaya alınan 169 olgunun %63’ü kadın olup yaş ortalaması 63,4±16,1 idi. Olguların %85,8’inde genotip1b, %4,2’inde genotip 1a, %0,6 2’inde genotip 2, %3’ünde genotip 3 ve %11’inde genotip 4 sapanmıştır. Genotip 1 olgularında yaş ortalaması (62,2±14,6) ve kadın cinsiyeti genotip 1 dışı olgulara göre belirgin olarak yüksek bulunmuştur. Yıllar içinde genotip 1b’de azalma saptanmazken genotip 4’te hafif bir artış belirlenmiştir. Sonuç: Genotip 1b en yaygın genotip olarak saptanmıştır. Hastaların ileri yaşta olup kadın cinsiyetinin daha fazla olması epidemiyolojik açıdan dikkati çekmektedir.

Özet

Objectives: It was aimed to determine the distribution of hepatitis C virus (HCV) genotypes among patients who had HCV infection, and to identify the demographic characteristics of these patients. Materials and Methods: Adult patients who underwent HCV genotyping between January 2016 and December 2019 in the microbiological laboratory of our hospital were included in the research. The age and gender of the patients were investigated retrospectively from the hospital registry. Results: 63% of the 169 patients who were included in the study were female and the mean age was 63.4±16.1. It was found out that of the patients, 85.8% were with genotype 1b, 4.2% with genotype 1a and 0.62% with genotype 2, while 3% of them had genotype 3 and 11% of them had genotype 4. It was determined that the mean age (62.2±14.6) and rate of female gender of patients who had genotype 1 was significantly higher than other patients. Whereas genotype 1b did not decline over the years, a slight increase was determined in genotype 4. Conclusion: It was found out that genotype 1b, was to be the most frequent genotype. The fact that most of the patients were female as well as they were elderly is epidemiologically remarkable.