Lectin Treatment Affects Malignant Characteristics of TPC-1 Papillary Thyroid Cancer Cells

Abstract

Objective: Abnormal glycosylation is a universal aspect of cancer cells. The altered glycosylation pattern has been originated from changings in expression of glycosylation enzymes which are up-regulating in reply to some oncoproteins in the biosynthetic pathway of glycans. In this study, it was aimed to show the presence of terminal α-2,3, α-2,6 sialic acid and α-1,6/α-1,2 fucose motifs in TPC-1 papillary thyroid cancer cells. Also it was aimed to examine the changes in viability and mobility of the cells after exogenously specific lectin treatment.