Journals / Selçuk Tıp Dergisi / 2000 / Cilt: 16 - Sayı: 3
Effects of nimodipine on tissue lactate and malondialdehyde levels in experimental head trauma
- Journal
- Selçuk Tıp Dergisi
- Pages
- 205–209
- DOI
- —
Abstract
In this study, we investigated the effects of nimodipine on tissue lactate (LA) and malondialdehyde (MDA) levels in rabbit brain one hour after experimental head trauma. The weight drop method was used to produce head trauma in 25 New-Zeland rabbits. The rabbits were divided into three groups. Group 1 was the sham operated group. Group 2 (control group) received head trauma only and in group 3 nimodipine was administered 20 µgr./kg (i.v) immediately after the head trauma via the jugular vein. In group 2 and 3 samples from the non contused side was named as "a" and contused side as "b". The tissue mean LA and MDA levels were 15.33±1.89 micromoles per gram wet weight (µmol/gww) and 66.21± 8.69 nanomoles per gram wet weight (nmol/gww) in group 1, 18.24±1.84 µmol/gww and 89.64 ± 9.65 nmol/gww in group 2a, 25.50±1.78 µmol/gww and 142.43±8.69 nmol/gww in group 2b, 18.67±1.81 µmol/gww and 91.09±11.86 nmol/gww in group 3a, and 25.25±1.95 µmol/gww and 137.60±9.59 nmol/gww in group 3b respectively. The results were found similar between the group 2 and 3. These results demonstrated that nimodipine has no effect on tissue LA and MDA levels in the early period of experimental head trauma.
Özet
Bu çalismada, deneysel kafa travmasindan 1 saat sonra nimodipinin doku laktat (LA) ve malondialdehid (MDA) seviyeleri üzerine etkilerini arastirdik. Yeni Zelanda tipi tavsanlara kafa travmasi olusturmak için agirlik düsürme metodu uygulandi. Tavsanlar 3 gruba ayrildi. Grup 1 sham grubu idi. Grup 2'ye yalnizca travma yapildi. Üçüncü grupdaki tavsanlara travmadan hemen sonra juguler ven yoluyla 20 mgr/kg dozunda nimodipin verildi. Ikinci ve üçüncü grupta travma yapilmayan taraftan alinan örnekler "a", travma yapilan taraftan alinan örnekler "b" olarak adlandirildi. Ortalama doku LA ve MDA seviyeleri sirasiyla grup 1'de 15.33 ± 1.89 mikromol/gram yas doku (mmol/gww) ve 66.21± 8.69 nanomol/gram yas doku (nmol/gww); grup 2a'da 18.24 ± 1.84 mmol/gww ve 89.64 ± 9.65 nmol/gww; grup 2b'de 25.50 ± 1.78 mmol/gww ve 142.43 ± 8.69 nmol/gww; grup 3a'da 18.67 ± 1.81mmol/gww ve 91.09 ± 11.86 nmol/gww; grup 3b'de 25.25 ± 1.95 mmol/gww ve 137.60 ± 9.59 nmol/gww olarak bulundu. Grup 2 ve grup 3 arasindaki farkliliklar istatistiksel olarak anlamli degildi. Bu sonuçlar, deneysel kafa travmasinin erken döneminde verilen nimodipinin doku LA ve MDA seviyeleri üzerine etkili olmadigini gösterdi.