Journals / Selçuk Tıp Dergisi / 2000 / Cilt: 16 - Sayı: 3
Comparison of neuromuscular blockade caused by rocuroniom and cisatracurium
- Journal
- Selçuk Tıp Dergisi
- Pages
- 157–162
- DOI
- —
Abstract
In this study, we aimed to compare the effects of cisatracurium besilat and rocuronium bromide on neuromuscular block. After Faculty Ethic Committee approval, 26 adult patients from ASA I-II class were included to the study. Patients were randomly divided into two groups. Anaesthesia induction was realized by 2mg/kg alfentanil + 5 mg/kg thiopental. Patients in group I (n:13) received 0.1 mg/kg cisatracurium, patients in group II (n:13) 0.6 mg/kg rocuronium for intubation. The maintenance of anaesthesia was done by 1-1.5 % isoflurane + 50/50 %, N2O/O2. Patients were evaluated by "Mallampati scale" before operation and by " Goldberg and Cromach scale" during operation for assesment of intubation quality. The onset of action (T95), duration of action (T25) and recovery time (T25-75) of neuromuscular blockade were recorded. Unpaired student's t test and Mann-Whitney U test were used for statistical analysis (p<0,05). There were no differences between the two groups with respect to hemodynamics parameters, recovery time, quality of intubation and demografic datas (p>0,05). The onset of action and the duration of action of neuromuscular blockade were shorter in group II (p<0,05). We conclude that althought both cisatracurium and rocuronium provide sufficient cardiovascular stability and intubation conditions, rocuronium may be choosen at situations which is required rapid intubation.
Özet
Çalismamizda cisatrakuryum ile rokuronyumun nöromüsküler blok üzerine etkilerini karsilastirmayi amaçladik. Fakültemiz etik kurul onayi alinan, ASA I-II grubundan 26 eriskin hasta çalismaya dahil edildi. Hastalar rastgele iki gruba ayrildi. Anestezi indüksiyonu 2 mg/kg fentanil +5mg/kg tiyopental sodyum ile saglandi. I.gruba 0.1mg/kg cisatrakuryum, II.gruba 0.6mg/kg dozda rokuronyum endotrakeal entübasyon için verildi. Anestezi idamesi % 1-1.5 isofluran + %50 N2O/O2 ile yapildi. Hastalar operasyon öncesi Mallampati, operasyon sirasinda ise entübasyon kalitesi yönünden Goldberg ve Cromach testleri ile degerlendirildi. Nöromüsküler bloga ait etkinin baslama zamani (T95), klinik etki süresi (T25), derlenme indeksi (T25-75) kaydedildi. Verilerin istatistiksel analizinde Unpaired Student's t testi ve Mann Whitney U testi kullanildi (P 0.05). Entübasyon zamani ve klinik etki süresi grup II'de kisa olarak bulundu (P<0.05). Rokuronyum ve cisatrakuryum yeterli kardiyovasküler stabilite ve entübasyon kosullari saglamasina ragmen hizli entübasyon gerektiren durumlarda rokuronyumun tercih edilebilecegi kanaatine vardik.