Journals / Selçuk Tıp Dergisi / 2001 / Cilt: 17 - Sayı: 4
İskelet kası iskemi reperfüzyon hasarının önlenmesinde mannitol etkili mi?
- Journal
- Selçuk Tıp Dergisi
- Pages
- 231–234
- DOI
- —
Abstract
Purpose: The aim of this study was to detect the effectiveness of mannitol's antioxidant capacity in the treatment of ischemia-reperfusion injury after acute peripheric arterial occlusion. Material and Methods: 20 healthy individuals and 32 patients with acute arterial occlusion were taken to study. Of the acute ischemia diagnosed patients, standard surgery was performed on 17 patients and surgery and mannitol infusion were given to 15 patients. Blood samples were taken from the deep veins and MDA, CPK, GSH-PX levels were measured in the acute ischemia diagnosed period and 120th minutes of the reperfusion. Results: MDA of mannitol treatment group in the ischemic period meaningfully increased in consideration with the control group. In consideration of reperfusion period with ischemic group in mannitol treatment MDA significantly decreased. In the reperfusion period of mannitol treatment GSH-PX significantly increased according to control group. Although the CPK results showed significant increase in each period of both treatments, the reperfusion period of mannitol treatment showed a significant decrease in CPK considering with it's ischemic period. Conclusion: In acute arterial occlusions it was shown that mannitol decreases the activity of free oxygen radicals, increases the antioxidant capacity, and decreases the tissue injury meaningfully.
Özet
Amaç: Akut periferik arteriyel tikanmayi takiben gelisen iskemi reperfüzyon hasarinin tedavisinde mannitolün antioksidan kapasitedeki rolünün ortaya konulmasi amaçlandi. Gereç ve Yöntem: Akut iskeminin saptandigi 32 hasta çalismaya alindi. 20 saglikli birey kontrol grubunu olusturdu. Hasta grubunun 17' sine standart cerrahi tedavi uygulandi, 15'ine cerrahi tedavi ile beraber mannitol infüzyonu yapildi. Iskemik dönemde ve reperfüzyonun 120. dakikasinda derin venden alinan kan örneklerinde MDA, GSH-PX ve CPK çalisildi. Bulgular: Mannitol tedavi grubunun iskemi dönemi MDA degeri; kontrol grubuna göre önemli ölçüde yüksekti. MDA degeri mannitollü reperfüzyon döneminde daha düsüktü. Mannitol tedavi grubunun reperfüzyon dönemindeki GSH-PX degeri kontrol grubuna göre daha yüksekti. CPK düzeyleri her iki tedavi protokolünün her döneminde kontrole göre önemli yükselis sergilerken; mannitol tedavisinin reperfüzyon dönemi kendi iskemik dönemine göre önemli azalma ortaya koydu. Sonuç: Mannitolün serbest oksijen radikal akitivitesini baskilayip, antioksidan kapasiteyi artirdigi ve doku hasarinda anlamli düsme meydana getirdigi ortaya kondu.