Journals / Solunum Hastalıkları / 2001 / Cilt: 12 - Sayı: 1
The analysis of the tuberculous cases found to have resistance for more than one drug in culture
- Journal
- Solunum Hastalıkları
- Pages
- 56–59
- DOI
- —
Abstract
Fourty cases, who had been in our clinic between 1995-1998 and having resistance for more than two drugs in antibi-ogram, were examined. As 70% of cases had a prior administration of antituberculous therapy (secondary resistance), there were not past therapy for other 30% of cases (primary resistance). Twenty-one cases (52.5%) were man, 19 (47.5%) were woman and the mean age was 40.3 (15-85). In primary resistance women and in secondary resistance men were higher, but the difference was meaningless with statistically (p= 0.112012). The mean age was 40.5 in primary resistant cases and 40.6 in secondary resistant ones. Cavity was seen in 75% of secondary resistant cases, on the other hand ca-ses without cavity were more frequent in primary resistant group. Synchronic disease was marked in eight (20%) cases. As the minority of the cases, the relation with the drug resistance were not accounted. In all, the number of drug resis-tance were found two for 37.5%, three for 55%, four for 7.7%. In secondary resistant cases; resistance were found for two drugs in 21.4% (6/28), three in 67.8% (19/28), four in 10.7% (3/28) and 66.6% (8/12), 33.3% (4/12), 0% in pri-mary resistant cases respectively. The difference were statistically significant (p= 0.0188).
Özet
1995-1997 yılları arasında kliniğimizde yatarak spesifik kültür antibiyogramlarında iki ve daha fazla ilaca direnç saptanan 40 olgu incelendi. Bu olguların %70'inde önceden tüberküloz ilacı alımı öyküsü var iken (sekonder direnç), %30'unda böyle bir öykü (primer direnç) olmadığı görüldü. Olguların 21'i (%52.5) erkek, 19'u (%47.5) kadın olup, yaş ortalaması 40.3 (15-85) idi. Primer dirençlilerde kadın, sekonder dirençlilerde erkek olgu sayısı yüksekti, ancak fark istatistiksel olarak anlamsızdı (p= 0.11201). Primer dirençlilerde yaş ortalaması 40.5, sekonder dirençlilerde 40.6 olarak bulundu. Kavite sekonder dirençlilerin %75'inde görülürken primer dirençlilerde kavitesiz olgular (%58.3) çoğunluktaydı (p= 0.049). Eşlik eden hastalık 8 (%20) olguda saptandı. Olguların sayısı az olduğundan ilaç direnci ile ilişkisi hesaplanamadı.Tüm olgular için %37.5 iki, %55 üç, %7.7 dört ilaç direnci bulundu. Sekonder dirençli olgularda %21.4 (6/28) iki, %67.8 (19/28) üç, %10.7 (3/28) dört ilaç direnci bulunurken, primer dirençlilerde bu oranlar sırasıyla %66.6 (8/12), %33.3 (4/12), %0 idi. Fark istatistiksel olarak anlamlı bulundu (p= 0.0188).