Acute Histopathological Response of Renal Tissues After Varied Fractionated Abdominal 12 Gy Irradiation In Rats

Abstract

Objective: The aim of the present study was to evaluate the effect of fraction dose irradiation on kidney damage due to scattered radiation.Methods: Rats were randomized into 6 groups. Group 1: Control group, a sham irradiation (n=5); Group 2: Hypofractionated total abdominal irradiation (TAI), total of 12 Gy (2 fractions in 2 days) (n=4); Group 3: Hypofractionated TAI, total of 12 Gy (3 fractions in 3 days; n=6); Group 4: Hypofractionated TAI, total of 12 Gy (4 fractions in 4 days; n=6); Group 5: TAI with conventional fractionation, total of 12 Gy (6 fractions in 6 days; n=6); and Group 6: TAI with conventional fractionation, total of 12 Gy (7 fractions in 7 days; n=6).Results: There was no statistically significant difference (p>0.05) between the hypofractionated group sets of Groups 3-4 (2.66±0.51) and 5-6 (1.83±0.40). However, a statistically significant difference was found in the comparison between Group 2 (3.75±0.51) and the group sets of Groups 3–4 and 5–6 (p<0.05).Conclusion: The present study demonstrated that hypofractionated TAI leads to more prominent acute tissue damage in the kidneys than does conventional irradiation