Ionol Derivatives from Euphorbia tirucalli

Abstract

A new ionol derivative, (2R,6S,9S)-2-hydroxy-3-oxo-α-ionol (1), together with three known analogues, (6S,9S)-6-hydroxy-3-oxo-α-ionol (2), (6R,9S)-3-oxo-α-ionol β-D-glucopyranoside (3) and (6R,9R)-3oxo-α-ionol β-D-glucopyranoside (4), were isolated from the ethyl acetate extract of the aerial parts of Euphorbia tirucalli. Their structures were elucidated by means of extensive spectroscopic methods and comparison with the data reported in the literature. The absolute configuration of 1 was deduced by comparing experimental and calculated ECD spectra and 13C NMR data. The ionol derivatives have been obtained for the first time from the genus Euphorbia