A New Acetylenic Compound and Other Bioactive Metabolites from a Shark Gill-derived Penicillium Strain

Özet

Nine chiral compounds (1−9) were isolated from the static fermentation culture of a shark gillderived fungus Penicillium polonicum AP2T1. These compounds include a new acetylenic aromatic ether (1, (-)- WA), four alkaloids (aurantiomide C (2), fructigenine A (3), cyclopenin (4) and cyclopenol (5)) and four oxygenated compounds ((R)-penipratynolene (6), (3S,4S)-3,4-dihydro-3,4,8-trihydroxyl-naphthalenone (7), verrucosidin (8) and norverrucosidin (9)). Their structures were elucidated by MS, NMR, optical rotation and circular dichroism (CD). In antimicrobial tests, compounds 1–4, 6 and 8–9 showed weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis, and/or Escherichia coli. Compounds 3, 8 and 9 also exhibited moderate toxicity against Artemia salina larva, and showed cytotoxicity against human colon cancer cell line HCT116.