The Effect of Nasal Packing orStenting on Oxidative Stress After Septoplasty

Özet

Septal deviation cause hypoxia which may raise oxidative stress. Nasal packing after septoplasty operation may increase oxidative stress. Different types of nasal packing may effect oxidative stress. Our aim is to investigate effect of nasal packing and nasal stenting after septoplasty operation on oxidative stressand investigate effect of septoplasty operation on oxidative stress.Study is a prospective cohort study. Fifty-fiveindividuals who has nasal septum deviation (NSD) one side total obstruction but no other diseases; ages 18-30; were included for this study. The NSD was diagnosed based on the presence of nasal obstruction complaint, anterior rhinoscopy and nasal endoscopy. Patients randomly divided in to two by the nasal packing type. In group 1 merocel, in group 2 Doyle Silicone Combo splintwith airway was used. To investigate oxidative stresslevels, preoperatively venous blood was taken. Nasal packing was removed second day of surgery and venous blood was taken just before removal. After 28 days of surgery to investigate effect of septoplasty on oxidative stress, venous sample was taken. We measured thiol/disulfide levels and ischemic modified albumin. For group 1 and 2 preoperative levels compare to nasal packing removal day levels there was significant difference for thiol levels(respectively, p=0.008, p=0.002).Exclude nasal packing type to investigate effect of septoplasty on oxidative stress; preoperative values of thiols compare to 28th day values weresignificant different (p<0.001). We found nasal packing or stenting type do not havedifferent effect on oxidativestress. Both thiol levels decrease. Unlike the literature; septoplasty has bad effect on thiol levels which is the defensive for oxidation, then thiol levels increases as the time progresses.