Cognitive Outcome after Surgery in Patients with Mesial Temporal Lobe Epilepsy

Günay GÜL,Demet KUŞÇU YANDIM,Mesude ÖZERDEN,Melek KANDEMİR,Fulya EREN,BEKİR TUĞCU,Cahit KESKİNKILIÇ,Nalan KAYRAK,DURSUN KIRBAŞ

Abstract

Introduction: The aim of the present study was to evaluate the neuropsychological outcomes of patients with medically intractable unilateral mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis (HS) treated either by anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SAH).Methods: This was a retrospective study where 67 patients who had undergone surgery for MTLE were evaluated. Thirty-two patients underwent ATL and 35 underwent SAH. All patients underwent a detailed neuropsychological evaluation before and 1 year after surgery.Results: The verbal memory outcome was unchanged after left-sided surgery, whereas learning capacity increased after right-sided surgery (p=0.038). The visual memory outcome improved after right-sided surgery. Improvement of executive functions, particularly in the resistance of interference pattern in the Stroop Test, shortened 5th card time (p=0.000), and decreased corrections (p=0.003), after right-sided surgery and increased attention (p=0.027) after left-sided surgery were observed. After both surgery types, although statistically insignificant, there was a marked decrease in incorrect answers in the Stroop Test, which

Özet

Amaç: Bu çalışmada anterior temporal lobektomi (ATL) veya selektifamigdalohipokampektomi (SAH) ile tedavi edilen hipokampal skleroza bağlı tek taraflı ve dirençli mesial temporal lob epilepsili (MTLE) hastalarda nöropsikolojik sonuçların değerlendirilmesi amaçlanmıştır