Journals / Optimal Tıp Derg. / 2002 / Cilt: 15 - Sayı: 3
Changes in malondialdehyde level and glutathione peroxidase, glucose-6-phosphate dehydrogenase and arginase activities in the systemic arterial hypertension
- Journal
- Optimal Tıp Derg.
- Pages
- 67–71
- DOI
- —
Abstract
In 25 patients with hypertension and 15 healthy individuals were investigated with regard to relationship between hypertension and glutathione peroxidase, glucose-6-phosphate dehydrogenase, arginase enzyme activities, malondialdehyde, creatine, urea, triglycéride, cholesterol, very low density lipoprotein, hemoglobin, hematocrit levels. In the patients with hypertension, glutathione peroxidase, glucose-6-phosphate dehydrogenase activities and hemoglobin levels decreased (p<0.05), although malondialdehyde (P<0.005), triglycéride, cholesterol, very low density lipoprotein (P<0.05) levels increased significantly. Whereas, no differences were found in arginase activities, creatine, urea, hematocrit levels (P>0.05). As a result of hypertension, oxidative stress could be increase and antioxidant defense mechanisms could be insufficient.
Özet
25 hipertansiyon tanısı konulan hasta ile 15 sağlıklı kişiden oluşan kontrol grubunda glutatyon peroksidaz, glukoz-6- fosfat dehidrogenaz, arginaz enzim aktiviteleri, malondialdehid, kreatin, üre, trigliserid, kolesterol, çok düşük dansiteli lipoprotein, hemoglobin, hematokrit düzeyleri ile hipertansiyon arasında bir ilişkinin var olup olmadığı araştırılmıştır. Hipertansiyonlu hastalarda glutatyon peroksidaz, glukoz-6-fosfat dehidrogenaz aktiviteleri ve hemoglobin düzeyleri anlamlı olarak azalırken (p 0,05). Hipertansiyon sonucu organizmada oksidatif stres artabilir ve antioksidan savunma mekanizması yetersiz kalabilir.