Gluconic acid aqueous solution: A bio-compatible media for one-pot multicomponent synthesis of dihydropyrano [2,3-c] pyrazoles

Özet

A new facile, green and efficient protocol was developed for synthesis of Dihydropyrano [2,3-c] pyrazoles using gluconic acid aqueous solution (GAAS), as catalyst and solvent under environmentally friendly conditions. The advantageous features of this methodology are the environmentally benign character, operational simplicity, high yield processing (91-96%), easy handling; reaction medium can be recycled and reused several times without significant loss of its efficiency. The synthesized compounds were evaluated for antimicrobial and antioxidant activity and also analyzed for ADME properties. The structure of compounds has been confirmed by IR, 1H NMR, 13C NMR, Mass spectrometry and elemental analysis.