Diagnostic accuracy of noncompacted-to-compacted wall ratio criteria on CMRI for the diagnosis of left ventricular noncompaction

Abstract

Objectives: To investigate the diagnostic accuracy of the current criterion, noncompacted-to-compacted (NC/C) wall ratio > 2.3 oncardiac magnetic resonance imaging (CMRI) for the diagnosis of left ventricular noncompaction (LVNC).Materials and Methods: We retrospectively enrolled 37 patients as an LVNC group and a total of 97 participants with ischemic,hypertrophic, and dilated cardiomyopathy and healthy controls as a control group. The NC/C ratio was measured perpendicularlyon short-axis cine images for segments 1-16 and four-chamber cine images for the apex during the end-diastole. The sensitivity,specificity, and diagnostic accuracy of NC/C ratio > 2.3 for the diagnosis of LVNC were calculated.Results: LVNC patients comprised 24 males (64.8%) and 13 females (35.2%) with the mean age of 29.24 ± 11.79 years. The NC/C ratio> 2.3 detected in all but one of the LVNC patients (97.3%). On the other hand, the specificity of NC/C ratio > 2.3 was 79.4% for thediagnosis of the LVNC patients. Using NC/C ratio > 2.66 and > 2.8 yielded 91.9% sensitivity and 97% specificity, and 81% sensitivityand 100% specificity, respectively.Conclusion: NC/C ratio > 2.3 might lead to overdiagnosis of LVNC. We suggest using higher NC/C cut-off value in individualswithout high clinical suspicion of LVNC.