Evaluation of antimicrobial activity of five Vincetoxicum taxa growing in Turkey

Özet

The antibacterial, antifungal and antimycobacterial effects of ethanolic extracts obtained from aerial parts and roots of five Vincetoxicum taxa (V. canescens subsp. canescens, V. canescens subsp. pedunculata,V. parviflorum, V. fuscatum subsp. fuscatum and V. fuscatum subsp. boissieri) were tested against two Gram (+) bacterial strains (Staphylococcus aureusandBacillus subtilis), three Gram (-) bacterial strains (Escherichia coli, Acinetobacterbaumanniiand Aeromonashydrophila),three fungal strains (Candida glabrata, Candida parapsilosis andCandida tropicalis) and Mycobacterium tuberculosisby using thebroth dilution method. Ethambutol, Isoniazid, Ampicillin and Fluconazole were used as reference antimicrobial agents. All tested extracts showed significant antibacterial activity against A.baumanniiwith MIC values ranging from 31.25 to 62.5 μg/ml when compared to reference drug Ampicillin with 125 μg/ml MIC value. Moreover, the extracts obtained from aerial parts of V. fuscatum subsp. boissieriand roots ofV. canescens subsp. pedunculata were found the most effective extracts against A.baumanniiwith 31.25 μg/ml MIC value.