Plasma lipids before and after oopherectomy and the effect of estrogen replacement therapy

Ooferektomi önce ve sonrasında kan lipidleri ve buna postoperatif estrojen replasmanın etkisi

Selma EKMEKÇİ,MÜZEYYEN GÜLNUR ÖZAKŞİT,M. Serdar OĞUZ,A. Rıza ODABAŞI,Oya GÖKMEN

Abstract

Plasma Lipids Before and After Oopherectomy and the Effect of Estrogen Replacement Therapy Plasma lipids and lipoproteins were measured in a group of 83 premenopausal women who would undergo hysterectomy and sal-pingooopherectomy. The weeks after the surgery, mean plasma triglycerid levels were found 78-113 percent increased (p<0.05) whereas elevation of mean plasma total cholesterol, LDL-c and VLDL-c levels weren't statistically significant. Conjugated equine estrogen therapy was started to every patient after nineth week of oopherectomy. During the replacement thera¬py plasma lipids and lipoproteins were still virtually at their postoperative levels in twelve weeks.

Özet

Histerektomi ve salpingoooferektomi planlanan 83 premenopozal kadında plazma lipid ve lipoprotetnleri ölçüldü. Cerrahiden 3 hafta sonra plazma trigliserit seviyesi %78-%l 13 artmış (p<0.05) bulunurken, plazma total kolesterol, LDL-c ve VLDL-c deki artışlar ista-tistiki önem göstermedi. Her hastaya ooferektomiden 9 hafta sonra konjüge equin estrojen tedavisi başlandı. Bu yerine koyma tedavisi sırasında 12. haf¬taya kadar plazma, lipid ve lipoproteinlerin aynı değerleri koruduğu gözlendt