Journals / Medical Network Klinik Bilimler ve Doktor / 2001 / Cilt: 7 - Sayı: 5
The effect of different therapy regimens on bone mineral density in postmenopausal women: A retrospective study
- Pages
- 591–594
- DOI
- —
Abstract
AIM: Our aim was to investigate the effects of one year treatment with alendronate or etidronate or calcitonin on bone mineral density (BMD) in postmenopausal women with osteoporosis. MATERIALS AND METHODS: 184 postmenopausal women with osteoporosis whose diagnosis had been made with BMD received different therapy regimens. Among these 184 patients with postmenopausal osteoporosis 128 had received 10 mg alendronate, 27 had received 400 mg cyclic ethidronate, and 29 had received 100 U calcitonin daily for one year. The pre- and post-treatment BMD values of the patients are investigated retrospectively. RESULTS: Pretreatment BMD values were 0.719±0.09 gr/cm2, 0.800±0.09 gr/cm2, and 0.763±0.09 gr/cm2 in the alendronate, ethidtronate, and calcitonin groups, respectively. Posttreatment BMD values were 0.758±0.10 gr/cm2, 0.829±0.06 gr/cm2, and 0.753±0.08 gr/cm2 in the alendronate, ethidronate and calcitonin groups, respectively. While there were significant increases in BMD in the alendronate (p<0.001) and the ethidronate (p=0.002) groups, there was an insignificant decrease in BMD in patients who had received group used calcitonin (p>0.05). CONCLUSIONS: Our results show that alendronate and etidronate are more effective than calcitonin in the treatment of postmenopausal osteoporosis.
Özet
AMAÇ: Bu çalışmada postmenopozal osteoporozlu hastalarda alendronat, etidronat ve kalsitoninin bir yıl süre ile kullanımının kemik mineral yoğunluğu (KMY) üzerine etkisini incelemeyi amaçladık. GEREÇ VE YÖNTEM: Kemik mineral yoğunluk ölçüm değeri ile osteoporoz tanısı konmuş toplam 184 postmenopozal hastadan 10 mg/gün alendronat kullanan 128 hasta, 400 mg siklik etidronat kullanan 27 hasta, 100 ünite/gün salmon kalsitonin kullanan 29 hastanın başlangıçta ve bir yıl sonunda ölçülen KMY ölçümleri retrospektif olarak incelendi. BULGULAR: Alendronat kullanan hastaların başlangıç KMY değerleri ortalama 0.719±0.09 gr/cm2, bir yıl sonraki KMY değerleri ise ortalama 0.758±0.10 gr/cm2 idi. KMY değerlerindeki % 5.9 artış anlamlı idi (p 0.05). SONUÇLAR: Çalışmamızda postmenopozal osteoporoz tedavisinde alendronat ve siklik etidronat tedavisinin kalsitonin tedavisine göre daha etkili olduğu saptandı