Helicobacter pylori prevalance and its association with gastrointestinal hormons (Gastrin and glucagon) in type 2 diabetes mellitus patients with dispeptic complaints

Dispeptik yakınması olan tip II diabetes mellituslu hastalarda Helicobacter pylori prevalansı ve gastrointestinal hormonlarla (Gastirin ve glukagon) ilişkisi

Adalet AKDEMİR,Nurgün A. ZENGİN,A. Kadir ERGEN,A. Baki KUMBASAR,Zekai KUYUBAŞI

Abstract

We frequently face dispeptic complaints in diabetic patients.The reason of this though not proven is thought to be in association with Helicobacter Pylori infection and gastrointestinal system hormones. In our study, in 22 type 2 diabetes mellitus and 30 non-diabetic patients with dispeptic complaints H.Pylori presence and it's association with gastrointestinal hormones gastrin and glucagon were studied.The prevalance ofH. Pylori infection was found as in disbetic patient %91 ,in non-diabetic group %66 (p<0.05) .Gastrin levels were found significantly higher in H.Pylori (+) patients then in H.Pylori(-) patients (p<0.005).Glucagon levels were not significantly related in H.Pylori (+) and H.Pylori(-) patients (p>0.005).

Özet

Diabetik hastalarda sıklıkla dispeptik yakınmalarla karşılaşmaktayız.Bunun sebebi kesin olarak belirlenmemiş isede Helicobacter Pylori enfeksiyonu ve Gastrointestinal(GİS) hormanlarla ilişkisi olabileceği üzerinde durulmuştur. Çalışmamızda dispeptik yakınması olan 22 tip II diabetli ,30 nondiabetik hastada Helicobacter pylori pozitifliği ve GİS hormonlardan Gastrin ve glucagon arasındaki ilişki incelendi .Diabetik hastalarda H.pylori prevelansı %91,nondiabetik grupta %66 bulundu. (p 0.05).

Keywords: Helicobacter pylori,Diabetes mellitus,Dispepsi,Gastrinler,Gastrointestinal hormonlar,Glukagon,Yaygınlık,Diabetes mellitus, insülin bağımsız