Antimicrobial Investigation and Synthesis of Novel 1H-Pyrazole-4- (5H)-yl Diazene Derivatives

Yeni 1H-Pirazol-4-(5H)-il Diazen Türevlerinin Sentezi ve Antimikrobiyal Aktivitelerinin İncelenmesi

Abstract

In this study, firstly, ethyl 1-(4-bromophenyl)-2-(1,3,5-triphenyl-1H-pyrazol-4-(5H)-ylidene)hydrazine (1), which has starting material, was synthesized. A series of new 1H-pyrazol-4-yl diazene (2a-h)derivatives were synthesized from reaction the obtained starting material and various hydrazines. The synthesizedcompounds were confirmed by spectral methods such as elemental analysis, IR and NMR. Antibacterial activity ofthe compounds were investigated by disc diffusion method against to Gram (+) and Gram (-) bacteria. Gentamicinand Cefotaxime antibiotics were used as the control group. None of the doses showed any antibacterial activitycompared to the control.

Özet

Bu çalışmada, ilk olarak başlangıç maddesi olan etil 1-(4-bromofenil)-2-(1,3,5-trifenil-1H-pirazol-4-(5H)-