Bisphenol A-Induced Histopathological Alterations on Small Intestine Tissues of Rats: The Protective Role of Taurine and Curcumin

Bisfenol A’nın Sıçan İnce Bağırsak Dokusunda Oluşturduğu Histopatolojik Değişiklikler Üzerine Taurin ve Kurkumin’in Koruyucu Rolü

Abstract

Bisphenol A (BPA) has endocrine-disrupting properties. The present study aimed to examine thepossible protective roles of curcumin and taurine against BPA-induced small intestine toxicity in rats. For thispurpose, forty-two adult albino male rats were divided seven equal groups: control, olive oil, curcumin (100 mgkg-1 daily), taurine (100 mg kg-1 daily), BPA (130 mg kg-1 daily), curcumin+BPA, taurine+BPA. After four weeks ontreatment small intestine tissues were examined for histopathological examinations. BPA caused seriously toxicityon small intestine tissues, but curcumin and taurine did not have completely protective effects of this damage.

Özet

Bisfenol A (BPA) endokrin bozucu özelliğe sahip bir kimyasaldır. Bu çalışmanın amacı, BPA’nın sıçan