Difficulties In Synthesis and Characterization of Viral Capsid Peptides

Abstract

Peptides and proteins play a central role in numerous biological and physiological processes in living organisms. Viral capsid pepdides are part of the viruses outer shell of genetic materials. Viruses are recognized by immune system via capsid peptides. Depending on this property of capsid peptides, totally synthetic vaccine prototypes can be developed. In this work we synthesised 3 different viral peptide sequences with microwave enhanced Solid Phase Peptide Synthesis SPPS method and characerized with LC-ESI-MS system. We briefly describe the difficulties in synthesis and characterization.