Journals / Communications Faculty of Sciences University of Ankara Series B Chemistry and Chemical Engineering / 1985 / Cilt: 31
ASYMMETRIC SYNTHESIS İN A REFORMATZKY REACTION PREPARATION OF OPTICALLY ACTIVE p-HYDROXY ACIDS
- Journal
- Communications Faculty of Sciences University of Ankara Series B Chemistry and Chemical Engineering
- Issue
- 1985 · Cilt: 31
- Pages
- 1–1
- DOI
- —
Abstract
Reaction of benzaldehyde with optically active bromoacetic ester derivative I in a Refor* matzky reaction gives, after hydrolysis of the resulting ester, laevorotatory B-hydroxy-Bphenyl phenyl-propionic acid. Moreover, reaction of ethyi bromoacetate with acetophenone in the pre¬sence of zinc and 1,2:5,6-di-Odsopropylideno-a-D-glucofuranose (II) is accompanied by partial asymmetric synthesis as is shownby hydrolysis of the resulting ester to laevorotatory B-hydroxy -B-phenylbutyric acid.