Journals / Turkish Journal of Chemistry / 2006 / Cilt: 30 - Sayı: 1
Studies on 2-Ethyl-3-carbmethoxy-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline Derivatives and Calcium Modulatory Activities
- Journal
- Turkish Journal of Chemistry
- Pages
- 109–117
- DOI
- —
Abstract
Twelve new compounds having a 2-ethyl-3-carbmethoxy-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline structure were synthesized, characterized and screened for their calcium modulatory activities. The calcium antagonistic activities of the compounds were investigated by tests performed on isolated rat ileum and lamb carotid artery. Compounds 1, 4, 8 and 9 showed considerable activity.Calcium channel antagonists inhibit muscle contraction by blocking the influx of Ca2+ through calcium channels and are used as antianginal and antihypertensive drugs 1−5. Nifedipine, with 1,4-dihydropyridine (DHP) moiety in its structure, is the prototype of this group.
Özet
Twelve new compounds having a 2-ethyl-3-carbmethoxy-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline structure were synthesized, characterized and screened for their calcium modulatory activities. The calcium antagonistic activities of the compounds were investigated by tests performed on isolated rat ileum and lamb carotid artery. Compounds 1, 4, 8 and 9 showed considerable activity.Calcium channel antagonists inhibit muscle contraction by blocking the influx of Ca2+ through calcium channels and are used as antianginal and antihypertensive drugs 1−5. Nifedipine, with 1,4-dihydropyridine (DHP) moiety in its structure, is the prototype of this group.