A Case of Progressive Multifocal Leukoencephalopathy During Chronic Lymphocytic Leukemia

Kronik Lenfositik Lösemi Seyrinde Görülen Progresif Multifokal Lökoensefalopati Olgusu

Abstract

A Case of Progressive Multifocal Leukoencephalopathy During Chronic Lymphocytic Leukemia Latent John Cunningham virus reactivates in immunosuppressed individuals and rarely it can cause Progressive Multifocal Leukoencephalopathy. 67-year-old male patient was admitted to the emergency service with a complaint of seizure and he was given diazem and phenytoin therapy with a diagnosis of status epilepticus. Chronic lymphocytic leukaemia in remission was found in his anamnesis. Lesion that could be compatible with Multifocal Leukoencephalopathy was detected in brain magnetic resonance imaging with contrast, perfussion magnetic resonance imaging and magnetic resonance spectroscopy. The case died in the fifth month of follow-up. This article has presented a case of rare Progressive Multifocal Leukoencephalopathy in the course of chronic lymphocytic leukaemia

Özet

Latent John Cunningham virüsü, immünsuprese kişilerde reaktive olup, nadiren Progresif Multifokal Lökoensefalopati gelişimine neden olabilmektedir. Altmış yedi yaşında erkek hasta nöbet geçirme yakınması ile acil servise başvurmuş ve status epileptikus tanısıyla diazem ve fenitoin tedavisi uygulanmıştı. Özgeçmişinde remisyonda kronik lenfositik lösemi tanısı vardı. Kontrastlı beyin difüzyon manyetik rezonans görüntüleme, perfüzyon manyetik rezonans görüntüleme ve manyetik rezonans spektroskopide Progresif Multifokal Lökoensefalopati ile uyumlu olabilecek lezyon saptandı. Olgu takibinin 5. ayında exitus oldu. Bu yazıda kronik lenfositik lösemi seyrinde nadir görülen Progresif Multifokal Lökoensefalopati olgusu sunulmuştur