Evaluation of the Relation Between Vascular and Cardiac Calcification and Osteoporosis, and Detection of Risk Factors in Patients Undergoing Hemodialysis

Özet

Introduction: Our aim in this study was to detect the presence and the grade of mitral and aortic calcification, and aortic stiffness, and the relationship between bone mineral density (BMD) and vascular calcification in patients undergoing hemodialysis. Methods: Patients participating in the hemodialysis program were included in the study. Echocardiography was performed to determine the presence of mitral and aortic calcification, as well as aortic stiffness. The BMD was measured using dual energy x-ray absorptiometry (DEXA) from the radial region of the arm without an arteriovenous fistula, and from the lumbar and femoral regions. The BMD values were classified as T and Z scores. Results: Sixteen female and 36 male patients were included in the study. Mitral valve calcification was detected in 22 (42.3%) and aortic valve calcification in 25 (48.1%) patients. Aortic valve calcification and aortic stiffness were correlated with age and parathormone. Aortic stiffness was correlated with the calcium–phosphorus product. There was a correlation between the radial region Z score and aortic stiffness. The radial region T score was consistent with osteoporosis in both genders. The results of the radial region BMD were associated with gender and duration of dialysis. Discussion and Conclusion: Age was associated with both aortic valve calcification and aortic stiffness, whereas aortic and mitral valve calcification and aortic stiffness were not correlated with the femoral, lumbar, and radial region bone mineral densitometry results. The DEXA results for the radial region may provide more accurate information about bone density in patients undergoing hemodialysis.