Evaluation of Clinical and Sociodemographic Features of the Patients' Who Had Hypomanic/Manic Switch Due to Drugs

İlaca Bağlı Hipomanik /Manik Nöbet Geçiren Olguların Klinik Ve Sosyodemografik Özelliklerinin ıncelenmesi

Abstract

Objectives: The aim of this study was to retrospectivelyevaluate sociodemographic and clinical features ofpatients who had hypomanic/manic switch during antidepressant treatment. Methods: In this study statisticalevaluations of retrospective chart reviews of majordepression patients who admitted to Private AdanaHospital between December 2012-August 2015, whowere above 18 years of age, who met DSM-IV diagnosticcriteria for major depressive disorder (HAM-D score>32), and who switched to hypomania (YMRS score>13) or mania (YMRS score >21) during antidepressanttreatment were performed. Significance level wasdefined to be p<0.05. Statistical Package for SocialSciences (SPSS) version 21.0 was used for statistical evaluation of the data. Results: This study included 33patients (21 females 12 males) who had manic or hypomanic switches during antidepressant treatment formajor depression. Mean age of the females was 32,57±7,06, and males was 28,50±6,84. Mean initial HAM-Dscore of these major depression patients was detected tobe 35.84±5.66. Mean duration of depressive illness was7.18±4.91 years and percentage of hospitalization fordepressive episodes was 1.72±1.68%. Seventeenpatients (51.5%) had a family history for bipolar disorder. A stressor was detected in 75.8% of the patients(n=25). Seasonality of the episodes was positive in45.8% (n=16) of the patients. Conclusion: Seventeenpatients (51.5%) had previous suicidal attempts. Afterantidepressant treatment 19 patients had manic (YMRS>21), and 14 patients had hypomanic (>13) episodes.

Özet

Amaç: Bu çaly?mada; antidepresan tedavi syrasynda hipomanik/manik kayma gözlenen hastalaryn geriye dönüksosyodemografik ve klinik özelliklerinin ara?tyrylmasyamaçlanmy?tyr. Gereç ve Yöntem: Bu çaly?ma, ÖzelAdana Hastanesi Psikiyatri poliklini?ine Aralyk 2012A?ustos 2015 arasynda ayaktan tedavi için ba?vuran, 18ya?yny doldurmu?, DSM-IV tany kriterlerine göre majordepres yon (HAM-D skoru >32) tanysy konmu? antidepresan tedavi almy? ve antidepresan tedavi altynda ikentakiplerinde hipomanAd?yaman Üniversitesi E?itim ve Ara?t?rma Hastanesiik (YMRS skoru >13) ve manik(YMRS skoru >21) kayma gözlenmi? olan hastalaryngeriye dönük dosya bilgilerinin taranmasy ve sosyodemografik verilerinin istatistiksel olarak dökümünün eldeedilmesi ile yapylmy?tyr. Anlamlylyk düzeyi p 21), 14'ühipomanik (>13) atak geçirdi?i tespit edildi.