Investigation of LFA-1 rs2230433 Variation in Renal Cell Carcinoma Tissues

Özet

Introduction: Leukocyte function-related antigen-1 (LFA-1) is αβ heterodimeric transmembrane glycoprotein and expressed on the surface of leukocytes. LFA-1 also interacts with intercellular adhesion molecules 1 (ICAM-1) which is related to cancer. Variation in LFA-1 can affect the carcinogenesis; thus, we aimed to investigate rs2230433 variation in renal cell carcinoma. Methods: One hundred renal cell carcinoma tissues and healthy surrounding tissue of the same kidney formed the tumor and control groups, respectively. DNA isolated from the tissues and polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods were employed. Statistical analysis was performed with SPSS 22.0, and p 0.05). However, GG genotype was higher in tumors (8%) than controls (2%). Discussion and Conclusion: Our results showed that normal GG genotype is higher in tumors. Thus, GG genotype can be related to tumorigenic features.