Journals / Turkish Journal of Chemistry / 2005 / Cilt: 29 - Sayı: 3
Synthesis, Characterization and Primary Antimicrobial Activity Evaluation of 3-Phenyl-6-methyl-4(3H)-quinazolinone-2-yl-mercaptoacetic Acid Arylidenehydrazides
- Journal
- Turkish Journal of Chemistry
- Pages
- 233–246
- DOI
- —
Abstract
3-Phenyl-6-methyl-4(3H)-quinazolinone-2-yl-mercaptoacetic acid hydrazide (3) was reacted with substituted aldehydes in absolute ethanol to obtain a new series, 3-phenyl-6-methyl-4(3H)-quinazolinone- 2-yl-mercaptoacetic acid arylidenehydrazides (4a-q). The structures of 4a-q were elucidated by elemental analyses and from spectrometric (UV, IR, 1H-NMR, 13C-NMR and EIMS) data. Then 4a-q were evaluated for antibacterial, antifungal and antitubercular activities. No significant activity was observed against the selected microorganisms.
Özet
3-Phenyl-6-methyl-4(3H)-quinazolinone-2-yl-mercaptoacetic acid hydrazide (3) was reacted with substituted aldehydes in absolute ethanol to obtain a new series, 3-phenyl-6-methyl-4(3H)-quinazolinone- 2-yl-mercaptoacetic acid arylidenehydrazides (4a-q). The structures of 4a-q were elucidated by elemental analyses and from spectrometric (UV, IR, 1H-NMR, 13C-NMR and EIMS) data. Then 4a-q were evaluated for antibacterial, antifungal and antitubercular activities. No significant activity was observed against the selected microorganisms.