Journals / Turkish Journal of Chemistry / 2011 / Cilt: 35 - Sayı: 2

Synthesis and characterization of novel benzovesamicol analogs

Pages
189–200
DOI
—

Abstract

Three new racemic vesamicol analogs were successfully prepared in good yields and high purity. All compounds were characterized by both IR and NMR spectroscopy. Compounds (\pm)-5 and (\pm)-6 showed a moderate lipophilicity compared with reference compounds IBVM and DRC140, respectively. However, the lipophilicity of DRC140 and (\pm)-9 showed very similar behaviors.

Özet

Three new racemic vesamicol analogs were successfully prepared in good yields and high purity. All compounds were characterized by both IR and NMR spectroscopy. Compounds (\pm)-5 and (\pm)-6 showed a moderate lipophilicity compared with reference compounds IBVM and DRC140, respectively. However, the lipophilicity of DRC140 and (\pm)-9 showed very similar behaviors.

Keywords: Benzovesamicol, ethylenedicysteine, vesicular acetylcholine transporter