Journals / Turkish Journal of Chemistry / 2010 / Cilt: 34 - Sayı: 6
Biotransformation of danazol by Fusarium solani and Gibberella fujikuorii, and prolyl endopeptidase inhibition studies of transformed products
- Journal
- Turkish Journal of Chemistry
- Pages
- 945–952
- DOI
- —
Abstract
Biotransformation of danazol (17b-hydroxy-17a-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium solani yielded 17b-hydroxy-2-(hydroxymethyl)-17a -pregn-4-en-20-yn-3-one (2) and 17b -hydroxy-2-(hydroxymethyl)-17a-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Gibberella fujikuorii yielded compound 2 only. The structures of these compounds were deduced on the basis of modern spectroscopic techniques. Prolyl endopeptidase inhibition activities of danazol (1) and its transformed products 2 and 3 are also studied.
Özet
Biotransformation of danazol (17b-hydroxy-17a-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium solani yielded 17b-hydroxy-2-(hydroxymethyl)-17a -pregn-4-en-20-yn-3-one (2) and 17b -hydroxy-2-(hydroxymethyl)-17a-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Gibberella fujikuorii yielded compound 2 only. The structures of these compounds were deduced on the basis of modern spectroscopic techniques. Prolyl endopeptidase inhibition activities of danazol (1) and its transformed products 2 and 3 are also studied.