Journals / Turkish Journal of Chemistry / 2008 / Cilt: 32 - Sayı: 5
Synthesis and Antifungal Activity of Some Novel N-(4-Phenyl-3-aroylthiazol-2(3H)-ylidene) Substituted Benzamides
- Journal
- Turkish Journal of Chemistry
- Pages
- 585–592
- DOI
- —
Abstract
Variously substituted N-(4-phenyl-3-aroylthiazol-2(3H)-ylidene)benzamides (2a-t) were prepared by base-catalyzed cyclization of corresponding 1-aroyl-3-aryl thioureas with acetophenone in the presence of bromine. Some of the synthesized compounds were assayed in vitro for their antifungal activity and were found to exhibit low to moderate activity.
Özet
Variously substituted N-(4-phenyl-3-aroylthiazol-2(3H)-ylidene)benzamides (2a-t) were prepared by base-catalyzed cyclization of corresponding 1-aroyl-3-aryl thioureas with acetophenone in the presence of bromine. Some of the synthesized compounds were assayed in vitro for their antifungal activity and were found to exhibit low to moderate activity.