Journals / Turkish Journal of Chemistry / 2013 / Cilt: 37 - Sayı: 5
Optimization of synthesizing glucose 1-phosphate by sodium tripolyphosphate as a phosphorus acylating agent using response surface methodology
- Journal
- Turkish Journal of Chemistry
- Pages
- 765–774
- DOI
- —
Abstract
With glucose as the starting material, sodium tripolyphosphate as the phosphorus acylating agent, and urea as the catalyst, glucose 1-phosphate was synthesized and its properties were analyzed. The synthesis conditions were selected according to the phosphorus content and optimized through the response surface methodology (RSM), based on a 3-level, 3-variable Box--Behnken experimental design. The results showed that the phosphorus content of glucose 1-phosphate was 8.12% using a reaction temperature of 70 °C, a molar ratio of glucose to sodium tripolyphosphate of 1.54:1, and catalyst amount of 3.7 g. It coincided well with the experimental value (8.34%). The structure of the product was confirmed by IR, UV, and 1H NMR spectra; electrical conductivity; TG; and DTA. The proposed method has high phosphorus content and low toxicity.
Özet
With glucose as the starting material, sodium tripolyphosphate as the phosphorus acylating agent, and urea as the catalyst, glucose 1-phosphate was synthesized and its properties were analyzed. The synthesis conditions were selected according to the phosphorus content and optimized through the response surface methodology (RSM), based on a 3-level, 3-variable Box--Behnken experimental design. The results showed that the phosphorus content of glucose 1-phosphate was 8.12% using a reaction temperature of 70 °C, a molar ratio of glucose to sodium tripolyphosphate of 1.54:1, and catalyst amount of 3.7 g. It coincided well with the experimental value (8.34%). The structure of the product was confirmed by IR, UV, and 1H NMR spectra; electrical conductivity; TG; and DTA. The proposed method has high phosphorus content and low toxicity.