Journals / Turkish Journal of Chemistry / 2014 / Cilt: 38 - Sayı: 2
Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold
- Journal
- Turkish Journal of Chemistry
- Pages
- 288–296
- DOI
- —
Abstract
Four 6-aminopenicillanic acid moieties were grafted at either rim of calix[4]arene, giving 2 novel generations of penicillin, which were named calixpenam. Antibiotic tests showed that they have amplified activity with respect to the corresponding penams against 3 gram-positive nonpenicillinase-producing strains of Streptococcus.
Özet
Four 6-aminopenicillanic acid moieties were grafted at either rim of calix[4]arene, giving 2 novel generations of penicillin, which were named calixpenam. Antibiotic tests showed that they have amplified activity with respect to the corresponding penams against 3 gram-positive nonpenicillinase-producing strains of Streptococcus.