Predictive Role of Mac-2 Binding Protein in Gastric Cancer Prognosis

Özet

Introduction: Gastric cancer is one of the most common and deadly cancers worldwide. Currently, it is becoming an over- prevalent malignancy in Turkey. Early diagnosis and treatment have a pivotal role in ameliorating the prognosis in patients with gastric cancer. Mac-2 binding protein (Mac-2BP) is expressed in many types of tissues, and recent studies have demon- strated that it is upregulated in various cancerous tissues. We investigated the expression of Mac-2BP in patients with gastric cancer, as well as its association with clinical and pathological variables. Methods: In this study, 130 patients, 90 patients with gastric cancer and 40 healthy controls were included. Serum Mac-2BP levels were measured in both groups. Clinical and pathological variables, including tumor size, histologic grade, primary tu- mor stage, lymph node metastasis, lymphatic invasion, vascular invasion, and neural invasion, were evaluated in the gastric cancer group. Results: Circulating Mac-2BP levels were higher in patients with gastric cancer than the control group. Serum Mac-2BP levels especially elevated in patients with larger tumor size, poor histologic grade, advanced primary tumor stage, lymph node metastasis, lymphatic invasion, vascular invasion, and neural invasion. Discussion and Conclusion: The findings obtained in this study suggest that serum Mac-2BP levels may have a predictive role in both gastric tumor diagnosis and prognosis.