Histological Findings of Organizing Pneumonia, Based on Transbronchial Lung Biopsy, May Predict Poor Outcome in Polymyositis and Dermatomyositis: Report of Two Autopsied Cases

Özet

Interstitial lung disease in polymyositis and dermatomyositis is a serious complication, associated with poor prognosis. In this article, we describe two cases with histological findings of organizing pneumonia (OP), based on transbronchial lung biopsy (TBB). One is a 66-year-old female patient with clinically amyopathic dermatomyositis (CADM) with anti-melanoma differentiation-associated gene 5 antibody, and another is a 61-year-old female patient with polymyositis with anti-Jo-1 antibody. Both of our cases rapidly deteriorated to death, and autopsy findings showed diffuse alveolar damage. Our experience indicates that TBB findings of OP may be a poor prognostic factor in CADM and polymyositis, in spite of the profile of myositis-specific antibodies.