Allerjik rinitli çocuklarda indoor ve outdoor inhalen alerjen prevalans›n›n araﬂt›r›lmas›

An investigation of the prevalence of indoor and outdoor inhalant allergens in children with allergic rhinitis

Abstract

Amaç: Bu çal›ﬂman›n amac›, ‹stanbul’da allerjik rinitli (AR) çocuklarda deri prick testi (DPT) reaktivitesine dayanan aeroallerjen duyarl›l›¤›n›n prevalans›n›n belirlenmesidir. Yöntem: Pozitif DPT olan 729 AR’li hastan›n dahil edildi¤i bu çal›ﬂma, üç yaﬂ grubu halinde incelendi. Bu hastalar üzerinde polen, ev tozu akarlar›, hayvan epiteli ve mantarlar içeren ekstraktlarla birlikte DPT yap›ld›. Araﬂt›rmaya dahil olan hastalar DPT’de en az bir alerjene karﬂ› pozitif olan bir tepkiye sahiptir. Bulgular: Pozitif DPT sonuçlar› olan 729 hastan›n alerjen prevelans›, ev tozu akarlar› için %33, polen için %31, mantarlar için %19 ve hayvan epiteli için %17 idi. Aeroalerjenlere karﬂ› duyarl›l›k, yaﬂ artt›kça belirgin olarak azald› (p<0.01). Okul öncesi çocuklarda (Grup 1) outdoor ve indoor alerjen pozitifli¤i 89 (%43.4), ergen çocuklarda (Grup 3) 32 idi (%15.6) ve alerjenlere duyarlılık da yaﬂ art›ﬂ›na göre belirgin olarak azald› (p<0.01). Sonuç: Bu çal›ﬂma ile istanbul'daki AR’li çocukların alerjen profili elde edildi. AR’li hastalar›n klinik yönetiminde sorumlu alerjenlere maruz kalmaktan kaç›nma ve AR için en iyi alerjen immünoterapi formülasyonunu bulma önemli adımlardır.

Özet

Objective: The aim of the present study was to determine the prevalence of the aeroallergens sensitivity among children with allergic rhinitis in the province of Istanbul in Turkey, based on skin prick test (SPT) reactivity. Methods:This study, including 729 AR patients with positive SPT, was conducted in three age groups. SPT with extracts including pollens, house dust mites (HDMs), animal dander’s (ADs) and molds was performed on these patients. All these patients have a positive reaction to at least one allergen with SPT. Results: The allergen prevalence of 729 patients with positive SPT results was 33% for HDMs, 31% for pollen, 19% for molds and 17% for ADs. The sensitivity to aeroallergens significantly decreased as the age increased (p<0.01). Both outdoor and indoor allergen positivity in preschool children (Group 1) were 89 (43.4%) and in adolescent children (Group 3) were 32 (15.6%), and also sensitivity to allergens significantly decreased according to increase of age (p<0.01). Conclusion: We provided regional allergens profile of children with AR in Istanbul. Avoiding exposure to allergens and finding the best formulation of allergen immunotherapy for AR are important steps in the clinical management of patients.