The Effect of Heparin on In Vitro Stimulated Platelet Aggregation by Elective Percutaneous Coronary Intervention

Özet

Background: The aim of the present study was to investigate the effects of heparin on in vitro stimulated platelet aggregation by elective percutaneous coronary intervention Methods: Thirty elective percutaneous coronary angioplasty (PTCA) patients were included in the present study. The patients were administered heparin as anticoagulant agent during PTCA. Two blood samples were obtained during the intervention before and 10 minutes after heparin bolus and stimulated platelet aggregation responses were investigated. Results: The difference in platelet aggregation response to adenosine diphosphate (ADP) before and after unfractionated heparin (UFH) was statistically significant (p 0.05). Conclusion: Heparin increases in vitro platelet aggregation stimulated with ADP in elective PTCA patients. This finding might explain the prothrombotic tendency of heparin, however further investigations are needed.