P190 BCR-ABL1 Transcript Prevalence in Iranian Children with Acute Lymphoblastic Leukemia

Özet

Objectives: Acute lymphoblastic leukemia (ALL) occurs due to the defective maturation of lymphoid cells and lack of differentiation. The present study was aimed to determine the prevalence of P190 BCR-ABL1 transcript in ALL patient and their relation with age, gender, and ethnicity in Iranian population. Methods: This cross-sectional research was done on 50 children with ALL including 28 (56%) males and 22 (44%) females. The presence of P190 BCR-ABL1 transcript was assessed by Nested-PCR technique. Results: From 50 ALL patients, P190 BCR-ABL1 transcript with e1-a2 fusion gene was positive in 2 (4%) cases, one patient (50%) male, and one female (50%) with <5 years old age range and Arab ethnicity. Conclusion: It seems that P190 BCR-ABL1 transcript prevalence and its relations with diagnosis and prognosis, age and ethnicity of ALL patients, need a higher population of the patients to better achievement in this field.