Brucellosis with p-ANCA-associated renal failure, leukocytoclastic vasculitis and endocarditis: Case report

Abstract

The relationship between brucellosis and p-antinuclear cytoplasmic antibody (p-ANCA)-associated vasculitis (pAAV) is a rare condition. Herein, we report a 52-year-old man who was diagnosed as rapidly progressive glomerulonephritis (RPGN) and endocarditis due to brucellosis. He was treated with antimicrobial agents, steroids, plasmapheresis, renal replacement therapy and aortic valve replacement. According to our best of knowledge, no similar case has been reported previously in the literature in regard to p-ANCA anti-lactoferrin antibodies associated-glomerulonephritis with brucellosis and endocarditis.