Unusual Radicular Cyst Formation Derived From Primary Teeth in Hyper Immunoglobulin E Syndrome

Abstract

Abstract Introduction Hyperimmunoglobulin E syndrome (HIES) is a rare genetic based multi-system disorder. It is characterized by high serum levels of IgE, pulmonary and recurrent skin infection except for these conditions abnormalities of the dentition, bones and connective tissue could be seen. The etiology of HIES is considered to be dominant-negative alterations in signal transducer and activator of transcription 3 (STAT3). STAT3 is integral to signal transduction for multiple cytokines. STAT3 is well expressed across tissue types. Case Report In this paper, we report a 7-year-old boy with HIES and a rare clinical manifestation regarding radicular cyst which is related to the deciduous tooth. Conclusion Chronic usage of antibiotics in the HIES patients can cause that sup-pressed serious lesion so that radicular cysts may be missed. Therefore, dentists should be alert on clinical and radiologic examination.