Potency of Aqueous White Grubs Extract Against CCl4 Induced Liver Diseases in Rats

Abstract

The potency of aqueous white grubs extract was assessed in the cure of carbon tetrachloride (CCl4) – induced lipoperoxidation in rats. The three different dosages were administered (1g/kg, 2g/kg and 8g/kg) daily to different groups of rats for up to 9 days after induced with lipoperoxidation using CCl4 at a dose of 120mg/kg. the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) activities as well as levels of serum malondialdehyde (MDA), total protein (TP) and albumin (ALB) of the rats after 9 days of white grubs administration were found to be similar to those of control rats (not CCl4 – treated). This shows possible curative effects of the white grubs extract, which was found to be depend on both the dose administered and the duration of treatment